I understand about the example. markj keeps talking about hunting as if hunting had anything to do with self defense in this situation. You tried to cater to his out of context references by bringing up self defense against a charging animal. That still isn't hunting, of course, but markj's responses still seem to indicate that just because it can be done, killing an animal with a .22, that somehow it means the caliber is suitable for self defense or has a strong likelihood of being effective in self defense.
You can kill a polar bear with an ice pick, but that doesn't make it a good weapon for self defense either.
"If you look through your scope and see your shoe, aim higher." -- said to me by my 11 year old daughter before going out for hogs 8/13/2011
My Hunting Videos https://www.youtube.com/user/HornHillRange