I have a Ruger M77 Hawkeye in 280 Rem. I worked up a load the other day. I used Barnes 140 Gr ttsx. I loaded 21 rounds up. I'm using Rem Brass, mag 215 primers. I went off of the Barnes reloading data Sheet. I calls for 53.5 to 57 gr of RL 22. Three rounds of each. 54, 54.5, 55, 55.5, 56, 56.5 and 57 at Barnes Red Line.
Every load I worked up was under a inch and a half. The two best loads were 56 Gr @ .75 inch group @ aprx 2910 fps and 55 Gr @ .5 inch group aprx 2850 fps.
My next run will be IMR 4350. It will be a 100 fps slower. Or I may just go with the 55 gr of RL 22.
On another note: It is a new rifle and a new scope. So I worked up a load with Hornady 120 Gr V-Max to get the rifle sighted in. I had .85 Groups with 55 Gr. of IMR 4350. Just pulled this one out of the book. shoots about an Inch Higher then the Barnes 140's.