Run. Its no longer a self defense situation.
While I agree with the run part (although we may not necessarily agree on the direction), I dont agree with the self defense part.
Self defense is self defense, if someone is putting your life at risk, distance has nothing to do with it.
Practicing and knowing you can make solid hits at those distances only increases your chances. For those that cry about the legal standpoint, being able to show you do make good hits in practice at those ranges, shows it wasnt a reckless or desperate act.