I am awaiting the cabal of empty chamber acolytes to chime in. You know, the Israeli Method dudes.
I carry one in the chamber at all times period. I am anti empty chamber carry. That said it is not only possible but quite easy to load the chamber one handed. It is part of a drill I practice which simulates loosing use of one arm during a shootout and needing to reload. You simply run the gun down your pants thru the waist,belt,pocket area on the side. The rear sight will drag on the pants and get pulled back loading the pistol.