All in all if you hit them with anything out of a shotgun it's very doubtful that he'll be going room to room from that point. Especially if peppered in the face.
I shoot enough skeet to feel comfident enough to know his chances of getting more than one round fired at him will be very high.
If there in the open and they hold still enough for you to hit them in the face, remember that at the short HD range your pattern is small. Oh and hopefully he doesn't subscribe to the OO buck theory and lets you have a second shot.