I have run my PX4 extremely dirty. 200 rounds of filthy, corroded, ~10 year old ammo followed by 200-250 of modern ammo. When I cleaned it, it took a LOT of time to get all the grime out. It never hiccuped. In nearly 2k rounds, it never has.
Beretta PX4 .40 S&W | Beretta 92FS 9x19 Para | Rock Island Armory GI 1911 .45 ACP | Colt Python 4" .357 Magnum | Colt 1968 Det. Spec. .38 Spc. | Ruger LCP .380 ACP | Daniel Defense M4V1 5.56x45 | Alpine M1 Carbine .30 | Steyr M1895 8x56 | Ruger 10/22 .22LR |1943 Izhevsk Mosin-Nagant M91/30 7.62x54R | Remington 870 12GA