I'm currently loading 5.1 gr. of Unique under 125 gr. Hornady bullet and yes the case is mighty full (90%). It appears that the bullet may, in fact, crush the powder just a bit but the respone of these loads on the range is very acceptable. I haven't experienced any over pressure signs - having shot 300 of these rounds.
All legal disclaimers apply here, your mileage may vary....etc.
The devil's strategy is to trivialize human existence and to isolate us from one another while creating the delusion that the reasons are; time pressures, work demands, or economic anxieties.
Dr. Phillip Zombardo. "The Age of Indifference"