I carry a Colt Combat Commander in .45 ACP. In it there are eight rounds counting the most important one that's up the snoot. The load is a 200gr Hornady HP-XTP, 6.1gr of Winchester-231 and a CCI LP primer. I've chronographed this load at 832 fps. I don't care how big the bad guy is, two of these just above the belt buckle and he will be a gut holding, quivering mass for a little while. Then he will be real quiet, just like a good boy should be.
There are three rules to follow. Your better judge by twelve than carried by six. Do it right and there will only be one liar in court. Your number one job is to go home at night.
Do it right.