One advantage on the GP100 (and most other Ruger DAs) is that it has a hard latch at the crane, in addition to the one behind the cylinder. When things go really bad as with that 15gr charge of Blue Dot, the cylinder will be held in line and the gun is more likely to survive if it's at all possible to do so! Had that cylinder come unlatched even the Ruger wouldn't have survived the bullet hitting the edge of the rear of the barrel instead of center.
The New Vaquero in 357 and other Ruger SA wheelguns are stronger yet
but the GP100 is a great balance of strength and packability in a DA platform.