the main problem I have with "tackling" is you typically have to weight till they are reloading.
even in a small revolver thats 5-6 shots.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 21 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple