Ive never been to africa, so those DG are out. In AK, the most DG I hunt is the black bear. I dont really have any interest in shooting a brown/griz, but I do plan for the worse. I always pick up a brown bear tag and carry a 458Lott w/500gr hornadies, a 45/70 w/400gr cast, or a 338 w/250gr X's.
If I run into a really nice brownie and its legal, I'll probably drop it, but I'm not gonna go out solely for them.