An awful lot of speculation and opinion, and vitually no experience. Who wants to be shot with a .22 or .25? Not me. Assassins have used the .22 with great success over the years. And a surprise shot to the face with a .25 will make someone look elsewhere immediately. A hit to the eye is probably instant death. A real killer with a .22 is to be feared infinitely more than some armchair hobbyist with a hand cannon.
Oderint dum Metuant