I'll take the 25acp over the 22lr in a pocket pistol. The ballistics normally cited for 22lr are from a rifle, or at least a target pistol, not a pocket pistol. 25acp fmj rounds can penetrate vitals and tend to be more reliable with their rimless centerfire design. I've seen some cheap 25 autos that were very reliable. Not my first choice in a defensive arm, but they serve a purpose.
Don't focus so much on who is driving the bus, but pay attention to what bus you're on and where it's going.