I shot 2 deer this year. The first was a medium sized doe. I shot it at about 50 yds. with a .54 cal round ball. I hit it in the neck and it dropped on the spot. It wasn't dead yet but it wasn't moving much either.
I just shot a large buck on Monday. 2 180 gr. Sierra soft points (303 Brit) through the lungs at 100 yds. One of them broke the opposite shoulder when exiting. The deer kept running like nothing was wrong. It took a third shot that broke the pelvis to put it down.