Since my HD scenario is to hole up, . . . call 911, . . . and defend my hole, . . . I'd do as previously mentioned: start with the 12 gauge, . . . transition to the Glock for more than one.
I seriously doubt, though if there were more than 1 bg in my place, . . . that the other(s) would want any part of me after they saw their partner in crime just get sucker punched by a 12 gauge load of 00 buck.
We're talking about an instantaneously made bloody mess, . . . one bg writhing in either unspeakable pain, . . . or his death throes, . . . an ear splitting crash of thunder (being in front of the 12 that just went "boom"), . . . and probably something about to trickle down the pants leg of the britches of any other bg's in the house.
Yeah, . . . go with the 12, . . . but do the practice thing so that you know how to do it. Also, . . . do you have anyone else with you there? They could reload the 12 for you, . . . as you stand overwatch with the Glock, . . . then trade out for round 2.
May God bless,
If you can breathe, . . . thank God!
If you can read, . . . thank a teacher!
If you are reading this in English, . . . thank a Veteran!