Not if you are legally able to posses them and they are legal where you started from. They could only be an issue if you stopped for more than incidental maintenance like eating and refueling. A week long visit with a friend or relative could be an issue for you but not while traveling through.
Just 2 cents from a dinosaur who drove by a Motel 6 once. That and something I read in The American Rifleman a long time ago from their legal beagles in answer to a letter with a similar question.
Good intentions will always be pleaded for any assumption of power. The Constitution was made to guard the people against the dangers of good intentions. There are men in all ages who mean to govern will, but they mean to govern. They promise to be good masters, but they mean to be masters.