There's more than just full auto in the NFA.
Would I use a full auto for home defense? Not likely. They're way too expensive to risk losing- too many stories of guns going missing while in police possession.
Would I use a SBR for home defense? Probably. I don't have one, but there's no extra lethality or anything over a non-SBR.
Would I use a suppressor for HD? Certainly. I plan to leave mine on my go-to AR once I get everything through the ATF. The suppressor can always be removed and kept. You can make a great case for a suppressor on the weapon as being a health and safety issue- permanent hearing loss is indeed permanent.