For me it's simple handguns, with my pacemaker the recoil of any long-gun more powerful than a .22 is a bad idea. So I prefer either my M&P 40 or my PT-22, whichever I can get to first depending on where I am, (as I am typing this the Taurus is on the table in front of me, and my M&P is in my e-vault by my bed).
Different people like different things. If i didnt have a pacemaker, my primary home defense would be a 12 gauge shotgun, and my pistols, but you play with the hand your dealt. So I think the answer is whichever gun you can make it to first.
Let not a man guard his dignity, but let his dignity guard him. -Ralph Waldo Emerson