Low and left shooting a lot of times comes from milking the grip... squeezing the fingers of the gun hand as well as the trigger. It's usually an attempt to mitigate recoil, but the shots print low and left.
You have to learn to hold the gun solidly with your hand and pull the trigger straight back using only your trigger finger. Then your shots should print to point of aim.
45 ACP: Give 'em a new navel!