Whoa, we're assuming that a shot needs to be fired!
Discharging a round is about fourth on the list of things you need to do for security! I fire Gold-Dots and don't worry about the FPS, the recorded "one shot stops" or the anecdotes in gun magazines. I don't even start my thought processes on this issue.
As I've stated before, my Dad worked for 42 years in the security industry. The single biggest factor for safety is good doors, windows and locks. Even Jeff Cooper utilized a color code for safety awareness that had many levels before firing.
Yikes, before I'd wonder about placement, bullet performance, number of shots to be fired or a situational combat mindset I'd desperately look for a safe exit.