I aim for the big toe, because I carry a .45, and if you get hit even in the big toe with a .45, you're going down.
Ha Ha. Always a wiseacre on every thread.
Now for a sensible analysis:
It's obvious that the recipient of such a wound, when anatomical information is considered along with the tactical solution, that he would be hopping around on one foot, therefore increasing the difficulty of followup shots.