I did some squirrells in the other day with my new .22 semi. It's a frankenstien built from a MagnumResearch 1017 receiver with Shooter's Ridge Fluted bull barrel and stock. I put a pretty decent scope on top and it's very accurate, and fun to shoot. My advice is to build your own so you can have it just the way you want it. Magnum Research also makes some killer lightweight barrels. (they cost a little more though.)
But the regular 10/22 right out of the box has taken more vermin than you shake a stick at. And the price is pretty agreeable.
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