I saw a Super Blackhawk years ago that was blown up. The shooter had tried Elmer's standard load of a 250 gr SWC and 22 gr of 2400.
Except he grabbed the wrong can and loaded 22 gr of Bullseye!
The top strap was gone, the frame bent and the tops of 3 chambers were blown. He wanted the gun sent back to Ruger for repairs!