I usually shoot a Colt Gold Cup and/or a S&W Model 19. I actually like the wheel guns a lot. The Colt just shoots real good for me so I use it now and again. I used to shoot Glocks but am temporarily out of them. I will have one again in the next few months.
As for which ones to shoot, if ya' got 'em, use 'em. Just make sure your proficiency doesn't slip with the ones you bet your life on. Shoot all -0s.