You won't lose any game to that load if you shoot it well.
Your second question can only be answered by shooting on paper, at the farthest range you intend to hunt. Hell just changing brands of bullets, of the same weight, is reason enough to confirm your zero & re-sight your rifle, as necessary.
“Nine-tenths of tactics are certain, and taught in books: but the irrational tenth is like the kingfisher flashing across the pool, and that is the test of generals. It can only be ensured by instinct, sharpened by thought practicing the stroke so often that at the crisis it is as natural as a reflex.” ~ T. E. Lawrence