While I carry a Kahr PM9 for deep concealment these days, I used to carry my Colt Mustang .380. I like the .32ACP. It's a soft shooting round and my 1903 Colt Hammerless is really accurate at combat range with the little .32, but the .380 has an edge over it. Both can be very effective with good shot placement, but that's true with any caliber. I wouldn't want to be on the receiving end of a well placed .22LR.