Longetivity and strength, depends, a $60 FIE ain't a Ruger single six. But generally yes a .22 revolver should last several lifetimes.
Penetrating a human skull, depends on ammo and the person, but generally yes, I shoot pigs in the head all the time with satisfactory results.
For self defence you need something else.
"Suppose you were an idiot, and suppose you were a member of Congress, but I repeat myself." Mark Twain