You need to think through your assertions a bit more thoroughly next time.
As do you, PBP. Iowa would have difficulty being independent while surrounded by an unfriendly neighbor, but California has the key ingredients for independence, even with an unfriendly neighbor.
Back to the legal aspect of this thread...
There is a huge gap between war or succession and silent acquiesence to federal overreaching. The trend of states voicing their displeasure with federal dominance may be a small step, but it is a positive one.