Personally speaking, I refuse to sacrifice my dog. In fact I know for a fact that one of my dogs, who happens to be a very mean looking member of a species of dog that supposedly "snap" on people, would hide behind me. He's done it before. If the animal gets close enough it's gonna get a bullet in the ear. Yes, I'll probably need a few stitches, but the bad dog will need a trash bag and a shovel.
A hit with a .45 ACP beats a hit with a .22 LR everytime. A hit with a .22 LR beats a miss with a .50 BMG everytime.