Well, i would go for hitting specific security elements rather than an over all design. Any design will work to your tactical favor, as long as you plan it out ahead of time. After all, it is your home turf, literally. Items like having a master light control in your master bedroom, to control house lighting from a central location, would be nice. Built-in gun storage areas in each room....maybe even to the point of sheetrocking a long gun behind a specific wall so that in an emergency the homeowner only has to smash the sheetrock to get at it ( that was covered on another board a while ago )....Top shelf locks and security components are invisible upon a casual inspection but still present. Open interior designs to help with visual tracking and fields of fire vs a compartmentalized room design can work either way, depending on the specific scenario you can come up with.
Information posted is personal opinion and should not be considered information released in an official capacity