I have not taken a deer with my GP-100 yet, but I'm looking forward to the chance. Larger deer from farther north or west, I would have reservations about, but these deer in North Florida often don't much bigger than a large dog.
My last 8 point probably didn't go 140 pounds on the hoof.
It's largely whether you can keep yourself to a reasonable range, as has already been mentioned. With my skill with a revolver and the 170 grain Gold Dot JSP, I think that 35-40 yards would be my longest shot that I could take with certainty of hitting what I want to. Bowhunting ranges it is for me.