If you limit your shooting distance, okay. I pretty much agree with Bud on this one. It is why I use a 480 Ruger SRH revovler, but I would be comfortable with my 41 mag. It is the 50-75 yd range that will get you. It is just a tad beyond the range you practice at, but the deer is there and you think you can make the shot. Again, that is why I use the 480.
Use a heavier load if you can.