Speaking from experience dont shoot a skunk! I got sprayed at close range and its wasnt a pleasant experience. Run.
I was on vacation in Alaska last month and stopped in at Ketchikan for the day. They have hundreds of these funny (varmits) at the dump. Theyre big furry 100-500lbs and can eat you. I'd love to varmit hunt those bad boys but would like something around 30-06.
My grandpa lives in the city and shoots rats from his porch with an air rifle. Air rifle gets my vote for those kind of pests.