I have been shooting a load that works really well in my 625 Mountain gun and my Vaquero.
5.1gr Clays Powder
Winchester LP Primer
250GR Hard Cast LRNFP & 250GR HDY HP/XTP
817 Published Velocity
My 625 is shooting 2inch. groups at 25 Yds. open sights
Not to bad for a 64 Year Old Blind Man.(Joking)