Hodgdon HS-6 is versitile stuff for all handgun calibers. Light loads to +P stuff. It works for 44 mag. but the Hodgdon H-110 is specifically tailored for large caliber magnum loads.
HS-6 burns reasonably clean at sufficient pressures. I don't load a lot of light stuff with HS-6. It's a bulky powder designed for medium to heavy pistol loads and shotgun loads.