All good advice here. Like Hutch, I don't like to hotrod my 45 Colt, but I do my .44 Mag. I am also pretty much standardized on two powders for these two cals - W296 (hard to tell this one apart from H110 in a lineup) and W231. I wouldn't worry too much about ruining your guns with H110, it would take a whole lot of shooting to make it noticeable (after cleaning), and then it is far from being ruined at that point.
[As for that tortured sentence, we just gotta work on that.
How about, "Anything I need to do can be done with those two."?]