I second Grafox's comment's. I have a 1955 Target and 2 625's (5" & 3") and they all shoot lead bullets great. One thing that I do with my 45 ACP revolvers is to use a seperate batch(one certain headstamp)of brass that only goes in my revolvers. I do this because I Redding profile roll crimp the ammo for my revolvers. I have found this to make things more consistant. As grafox said, experiment with some different loads and bullets.
NJW in AZ