I'm a fan of TightGroup, for all my lead shooting. From very mild 4.5gr loads to sub-magnum 9.2gr loads. My Hornaday book says I can use up to 10gr, but my Vaquero leads up to much with that much powder.
2400 and unique left to much residue for me... Well, so does H110, but the real reason I like TG is that it is consistent throughout the temperature range where I shoot. South Central Idaho. Subzero winters and scorching summers.
Oh, and I use Winchester Large Pistol primers.