Back when Roy WEatherby was first touting his high velocity rigs, there was a photo of a full-grown Eland which had been taken. I don't recall if it were the .257 or .270 Weatherby. Anyway, the shot was through the hams, side to side. A one-shot kill, it was said, with the animal falling where it was shot--not tracked and found after bleeding out. The exit wound looked to be maybe 8" or 10" across, with a really deep crater.
Animal behavior after being shot with a high-velocity bullet is definitely different than when hit by a slow-moving bullet.