It would depend on what you're shooting, no?
If you're hunting, .308 thru .338 ...well...seems best to limit shots to 250 yards. It's more ethical, and you're actually hunting.
If you're shooting paper, .308 is cheap, .300 Winmag can move a 175Gr SMK faster than .308 Win to keep 'em supersonic at 1000 yards. .338 shooting a lot of paper could be recipie for developing a flinch. And .50 BMG would result in a silly grin AND the flinch.