I carry a jframe in my weak side front pocket opposite my IWB carry gun.
The reason? I don't remember where I read it but I remember reading that hand injuries are very common in shootings because people tend to tunnel in in the threat (weapon) first. I would hate to be involved in a self-defense shooting and my only weapon be put out of commission.
Besides, the jframe is so easy to carry, it's not like I am going out of my way.