Another vote for Lil' Gun in 454 Casull.
Another powder for 454 I have used and gotten good results is AA1680. Slightly slower than the W296/H110 twins, I get a better SD.
But you just cannot beat Lil' Gun in big bore pistol...
.45 Super... Fat and FAST... but for real firepower, .45 Blackhawk!
Yes, in fact I do have a 454... in more ways than one.
"No provision in our Constitution ought to be dearer to man than that which protects the rights of conscience against the enterprises of the civil authority" - Thomas Jefferson