I have a TC Cherokee .45 that has neatly taken many Sitka blacktail deer, using either Buffalo 300+grain bullets or Hornady 300 Great Plains. I have a tang peep sight, and have shot cloverleafs at 100 yards from the bench. Most of the time the bullet exits, even on quartering shots. None of the deer go far.
This piece weighs only 6.5 pounds, and smacks the shooter almost as hard as the target. Those curved buttlplates and thin combs ain't comfy, but they sure are pretty. Plus, I have a .32 barrel for it, and that is fun.