As you can tell from other threads and my posts, I have a hangup about clean kills.
I know what CAN be done with the Big 50 if everything goes just right--but I'm always planning for the what-ifs when it all goes to garbage. I work on the assumption that if you're shooting at a fella, he must be a bad guy, so I'm unconcerned about where he's hit.
I got respect for critters, so when the word "hunting" is used, my personal definition of "perfection" comes in. Perfection is that package of skill, cartridge-energy, and bullet placement such that the critter never knows there was a problem. Range is thus a factor, as has been commented on above.
So it seems to me that if you have lotsa time to setup your benchrest gun on your portable benchrest, and have your superb rangefinder all dialed in, you're off to a good start. You've gotten Longpath to get the rust off his Trig, got your computer's trajectory tables all wired in, and your anemometer is all hooked into your laptop.
You got an anemometer out at 1,000 or 2,000 yards? "What if"?
A number of years ago, I knew guys who would go to Colorado with 7mm Rem Mags, rangefinders, spotting scopes and such, and two or three would sit and glass an opposite hillside at 600-800 yards. They'd spot a resting elk, and start shooting. The spotters would call corrections. I asked about success rate, compared to "wounded and got away". Well, too many got away...
So I guess that if you wanna shoot five-gallon buckets of dynamite or such, come on down and I'll supply the dynamite...But I'm just real uncomfortable about "hunting" at these ultra distances...