Yes, people do hunt with these. You should check out Dan Lilja's website (www.riflebarrels.com) because he has a really good article on long-range hunting. In summary, common everyday cartridges (.338 Lapua, etc.) built on small single-shot bolt actions are good to 1,200+ yards in the right hands. Large ones built on the .50 BMG are good to 2,000+ yards in the right hands and under the right conditions. Besides the other manufacturers already mentioned, Hornady also makes the .510" A-Max.