From my experience with 45ACP is:
After I started driving them above "pretty hot" to "damn hot", the accuracy tended to go away pretty quickly, not to mention they are unpleasant to shoot.
I am only speaking for Autoloaders that I have owned (1911's and more modern double action autos) I have never owned any wheels guns in 45.
There seems to be an area of loadings that shoot very good for the 45's I have owned. To slow, poor accuracy. To fast, same thing.
I found that anything over 900 fps with a 230gr bullet didn't seem to work so well for me.
Your mileage may vary.