Colt man, My vote goes for the 44 Mag. Rifle. If the shots are within 100yds. or less. Loaded with a nice gas checked, hard cast flat face hunk-o-lead. An LBT design comes to mind. I've loaded a 280 gr. LBT with 22.5 grs. of WW296(Worked up to carefully) for a real smasher load. Used on deer out of a pistol, complete penetration, golf ball exit wound.
The LBT designs leave more powder space in the case due to the design.
Just my humble opinion.