As iamkris mentions, the general consensus, although I've never tried it myself, seems to be that rifled slugs aren't very accurate through rifled barrels. Only thing to look out for after shooting is leading on the rifling.
But, since rifled slugs can be had pretty cheaply, at least here in OH at less than $2/5 rounds, why not try it out and see for yourself? I'd try it just to see but don't have a rifled barrel. Who knows? Maybe you might find a slug load that will work great.
- Ron V.